Dengue 2 (New Guinea C strain) Virus Infection Induces Apoptosis

Authors

  • S Abu Bakar
  • N Shafee

Abstract

The ability of dengue 2 virus infection to induce apoptosis was investigated. Dengue 2 virus-infected African green monkey kidney cells {Vera}. showed the presence of about 2. 9'. 22 and 30 percent apoptotic cells on day 3. S. B. and 11 postinfection. respectively. Increased number of apoptotic cells corresponded with increasing number of dengue 2 antigen positive cells. Induction of internucleosomal DNA fragmentation. characteristic of apoptotic cells, was noted also in dengue 2 virus-infected mosquito cell (C6f36) cultures. These results suggested that dengue 2 virus infection in nitro stimulated apoptotic cellular responses.

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Published

1997-06-30

Issue

Vol. 2 No. 1 (1997)

Section

Research article

License

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