THE STRUCTURES, PROPERTIES, SYNTHESIS, AND INNOVATIVE APPLICATIONS OF GOLD NANOPARTICLES IN LABORATORY MEDICINE: A REVIEW

Received 2023-01-07; Accepted 2023-04-10; Published 2023-06-06

Authors

  • Nordiyana Ishak Clinical Diagnostic Laboratory, Pusat Perubatan Universiti Sains Malaysia Bertam, 13200 Kepala Batas, Pulau Pinang, Malaysia.
  • Muhammad Azrul Zabidi Department of Dental Science, Institut Perubatan dan Pergigian Termaju, Universiti Sains Malaysia, Bertam, 13200 Kepala Batas, Pulau Pinang, Malaysia.
  • Siti Salmah Noordin Department of Clinical Medicine, Institut Perubatan dan Pergigian Termaju, Universiti Sains Malaysia, Bertam, 13200 Kepala Batas, Pulau Pinang, Malaysia.

DOI:

https://doi.org/10.22452/jummec.sp2023no1.22

Abstract

Nanoparticles technology has gained a great deal of interest in medical and non-medical fields. Gold nanoparticles (AuNPs) which are one of the most attractive metal nanoparticles are widely used in many biomedical fields either for therapeutic or diagnostic purposes. The properties of AuNPs, such as their stability, high biocompatibility, large surface area, relatively inert element, and tunable chemical and physical characteristics have enabled a wide range of applications and discoveries. The AuNPs can be synthesised chemical, physical, or biological synthesis. It is prepared through top-down or bottom-up methods depending on the starting material preparation. AuNPs are used in assays to detect diagnostic markers and specific nucleic acid sequence. Additionally, it is also used in assays to improve bacterial species identification. This review article provides a general overview of the structures, properties, synthesis, and various innovative applications of AuNPs in laboratory medicine such as in chemical pathology, immunology, haematology, molecular, cytogenetics, and transfusion medicine laboratories.

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Published

2023-06-06

Issue

Special Issue 1 (2023) Complementary Therapy, Diagnostic and Advanced Material in Medical and Dentistry

Section

Research article

License

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